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ISO 23970:2021

Milk, milk products and infant formula — Determination of melamine and cyanuric acid by liquid chromatography and tandem mass spectrometry (LC-MS/MS)

Sep 16, 2021

General information

90.20     Jul 15, 2026

ISO

ISO/TC 34/SC 5

International Standard

67.100.10  

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Scope

This document specifies a method for the determination of melamine and cyanuric acid with liquid chromatography in combination with tandem mass spectrometry (LC-MS/MS). The method has been validated in an interlaboratory study via the analysis of spiked samples of milk-based infant formula, soy-based infant formula, milk powder, whole milk, soy drink and milk chocolate ranging from 0,71 mg/kg to 1,43 mg/kg for melamine and 0,57 mg/kg to 1,45 mg/kg for cyanuric acid. The limits of quantification (LOQ) for melamine and cyanuric acid in food are 0,05 mg/kg and 0,25 mg/kg, respectively. The upper limit of the working range is up to 10 mg/kg for melamine and up to 25 mg/kg for cyanuric acid.

Life cycle

NOW

PUBLISHED
ISO 23970:2021
90.20 Standard under periodical review
Jul 15, 2026

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